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	Provedor de dados Biol. Res. (1) BABT (1) BJMBR (1) Autor Barbisan,Luis Fernando (1) Bueno,Aline (1) Calderon,Iracema Mattos Paranhos (1) Costa,Elaine (1) Damasceno,Débora Cristina (1) Du,L.Z. (1) FIGUEROA,YARA (1) FOSTER,DOUGLAS L (1) Fu,L.C. (1) He,Q. (1) LOBOS,ALEJANDRO (1) Liu,X. (1) Lv,Y. (1) PADMANABHAN,VASANTHA (1) RECABARREN,SERGIO E (1) Rodrigues,Marcela Marcondes Pinto (1) Rudge,Marilza Vieira Cunha (1) SIR-PETERMANN,TERESA (1) Saito,Felipe Hiroshi (1) Zhong,Y. (1) Mais... Palavra-chave IUGR (3) Apoptosis (1) Cell proliferation (1) Diabetes (1) Fetal programming (1) Kv1.5 (1) PASMCs (1) Pituitary sensitivity (1) Placenta (1) Pulmonary hypertension (1) Rat (1) Tyrosine phosphorylation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Journal article (1) Ano 2017 (1) 2012 (1) 2007 (1) País Brazil (2) Chile (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Evaluation of cell proliferation and apoptosis in placentas of rats with severe diabetes BABT Rudge,Marilza Vieira Cunha; Costa,Elaine; Barbisan,Luis Fernando; Damasceno,Débora Cristina; Bueno,Aline; Saito,Felipe Hiroshi; Calderon,Iracema Mattos Paranhos; Rodrigues,Marcela Marcondes Pinto. The aim of this work was to analyze the cell proliferation and apoptosis indexes on the 18th and 21st days of pregnancy of diabetic rats and to correlate with maternal glycemia and perinatal outcomes. Placentas from 20 Wistar rats were collected and divided into four experimental groups: control and diabetic of 18 and 21 days of pregnancy. The cell proliferation was analyzed using the PCNA expression and apoptosis by the TUNEL method. It was observed that PCNA and TUNEL indexes decreased from day 18 to 21 of pregnancy in the placentas of diabetic rats and these values were lower than control groups. Diabetic dams presented higher percentage of small for pregnancy age (SPA) fetuses. However, there was no difference between the PCNA and TUNEL indexes in SPA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Cell proliferation; Apoptosis; Placenta; Rat; IUGR. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200009 Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep Biol. Res. RECABARREN,SERGIO E; LOBOS,ALEJANDRO; FIGUEROA,YARA; PADMANABHAN,VASANTHA; FOSTER,DOUGLAS L; SIR-PETERMANN,TERESA. Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related changes in pituitary and gonadal responsiveness to GnRH in the male sheep. We used the GnRH agonist, leuprolide (10 µg/kg), as a pharmacologic challenge at 5, 10, 20 and 30 weeks of age. These time points correspond to early and late juvenile periods and the prepubertal and postpubertal periods of sexual development, respectively. LH and T were measured in blood samples collected before and after GnRH agonist administration. The area under the... Tipo: Journal article Palavras-chave: Fetal programming; IUGR; Pituitary sensitivity. Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400007 Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension BJMBR Fu,L.C.; Lv,Y.; Zhong,Y.; He,Q.; Liu,X.; Du,L.Z.. Intrauterine growth retardation (IUGR) is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated potassium channel 1.5 (Kv1.5) in this prenatal event that results in exaggerated adult vascular dysfunction. A rat model of chronic hypoxia (2 weeks of hypoxia at 12 weeks old) following IUGR was used to investigate the physiological and structural effect of intrauterine malnutrition on the pulmonary artery by evaluating pulmonary artery systolic pressure and vascular diameter in male rats. Kv1.5... Tipo: Info:eu-repo/semantics/article Palavras-chave: IUGR; Kv1.5; PASMCs; Pulmonary hypertension; Tyrosine phosphorylation. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100604 Registros recuperados: 3 Primeira ... 1 ... Última

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